All bone formation is determined by endothelial cells, hematopoietic stem cells, mesenchymal stem cells,
and their supporting accessory cells recruited at defective sites.
Autologous bone marrow stem cells can be the best choice in bone grafting.
Bone marrow extracted from the iliac crest is an optimal source of regenerative cells for angiogenesis, bone formation and healing.
Stimulate angiogenesis, release BP-2, and BP-6, and up-regulate the production fo BP-2
Orchestrate bone formation and directly convert to stromal stem cells (SD34+)
Convert to osteoblasts in support of the new bone formation
Mediate cell-to-cell adhesion through the release of various adhesion and growth factors
such as SDF-1α
Support the migration and proliferation of Endothelial progenor cells
Reaese casculat endothelial growth factors in support fo angio genesis
|Pre-Bone marrow||SMART M-CELL2 BmSC|
|TNC (x10³/㎕)||14.30 ± 3.75||70.51 ± 21.65|
|WBC (x10³/㎕)||13.09 ± 3.12||64.68 ± 18.79|
|CD34 + (/㎕)||68.67 ± 33.14||329.96 ± 179.82|
|BmSC+③ 30||Bone marrow stem cell separate and concentrate kit 30ml||Provide 3.5ml of Total cell from 30ml of whole blood|
|BmSC+③ 60||Bone marrow stem cell separate and concentrate kit 30ml||Provide 10ml of Total cell from 60ml of whole blood|
|BmSC+③ 120||Bone marrow stem cell separate and concentrate kit 60ml||Provide 20ml of Total cell from 120ml of whole blood|
|BmSC+③ 240||Bone marrow stem cell separate and concentrate kit 120ml||Provide 40ml of Total cell from 240ml of whole blood|